A mild, copper-catalysed amide deprotection strategy: use of tert-butyl as a protecting group
نویسندگان
چکیده
منابع مشابه
Deprotection of t-Butyldimethylsiloxy (TBDMS) Protecting Group with Catalytic Copper (II) Chloride Dihydrate
The protection of functional group is unavoidable in multi-step organic synthesis. Along with tetrahydropyranyl (THP) ethers, t-butyldimethylsilyl (TBDMS) ethers have been widely used for protecting hydroxyl groups. TBDMS ether is more stable to hydrolysis than trimethylsilyl ether, but is still readily cleaved by a variety of selective conditions. The deprotection of TBDMS is usually under mil...
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a large number of single research studies on the effects of strategy-based instruction (sbi) in teaching english as a foreign or second language has been conducted so far. however, the lack of a comprehensive meta-analysis targeting the effectiveness of english language sbi is observed. moreover, the findings of experimental studies regarding the context of the english language, proficiency lev...
A mild hydration of nitriles catalysed by copper(ii) acetate.
A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.
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چکیده: هدف اصلی این مطالعه ی توصیفی تحقیقی در حقیقت تلاشی پساروش-گرا به منظور رسیدن به نتیجه ای منطقی در انتخاب مناسبترین راهکار آموزشی بر گرفته از چارچوب راهبردی مطرح شده توسط والدمر مارتن بوده که به بهترین شکل سازگار و مناسب با سامانه ی آموزشی ایران باشد. از این رو، دو راهکار آموزشی، راهکار ارتباطی و راهکار بازساختی، برای تحقیق و بررسی انتخاب شدند. صریحاً اینکه، در راستای هدف اصلی این پژوهش، ر...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2014
ISSN: 0040-4020
DOI: 10.1016/j.tet.2014.07.080